MolNFT v1 · #39318 · protein

Conformation of the acrb multidrug efflux pump in mutants of the putative proton relay pathway

2HQF · Acriflavine resistance protein B: “Conformation of the acrb multidrug efflux pump in mutants of the putative proton relay pathway”. X-ray diffraction, 13 pockets (best druggability 0.84). MolNFT v1 #39318 on GenesisL1: 3D structure…

PDB: 2HQF
Type: protein
Length: 1,016 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acriflavine resistance protein B
UniProt: P31224
Pockets: 13 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Acriflavine resistance protein B	protein	1016	42% helix, 16% strand	P31224

Pockets

13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	753	0.84	0.88	90	empty
2	136	0.73	0.92	24	empty
3	143	0.65	0.87	25	empty
4	237	0.62	0.80	29	empty
5	81	0.62	0.89	21	empty

Compared structures

2HQF · Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay… · the same entry in another collection · chain A against A, TM-score 1.00
P31224 · AlphaFold monomer V2.0 prediction for multidrug efflux pump subunit acrb (P31224) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31224
Elsewhere: RCSB PDB 2HQF · PDBe 2HQF · UniProt P31224

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