MolNFT v1 · #39317 · protein
Crystal structure of human P100 tudor domain: large fragment
2HQE · P100 co-activator tudor domain: “Crystal structure of human P100 tudor domain: large fragment”. X-ray diffraction, 2 pockets (best druggability 0.50). MolNFT v1 #39317 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2HQE
- Type
- protein
- Length
- 304 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- P100 co-activator tudor domain
- UniProt
- Q7KZF4
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | P100 co-activator tudor domain | protein | 217 | 32% helix, 30% strand | Q7KZF4 |
| B | P100 co-activator tudor domain | protein | 87 | 24% helix, 32% strand | Q7KZF4 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.50 | 0.79 | 24 | empty |
| 2 | 124 | 0.38 | 0.73 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 453 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2HQE · Crystal structure of human P100 Tudor domain: Large fragment · the same entry in another collection · chain A against A, TM-score 1.00
- Q7KZF4 · AlphaFold monomer V2.0 prediction for staphylococcal nuclease domain- containing protein… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7KZF4
- Elsewhere: RCSB PDB 2HQE · PDBe 2HQE · UniProt Q7KZF4
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