MolNFT v1 · #39233 · protein
Crystal structure of a dipeptide complex of the Q58V mutant of bovine neurophysin-I
2HNV · Oxytocin-neurophysin 1: “Crystal structure of a dipeptide complex of the Q58V mutant of bovine neurophysin-I”. X-ray diffraction, 2 pockets (best druggability 0.79). MolNFT v1 #39233 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2HNV
- Type
- protein
- Length
- 415 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Oxytocin-neurophysin 1
- UniProt
- P01175
- Pockets
- 2 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Oxytocin-neurophysin 1 | protein | 83 | 20% helix, 39% strand | P01175 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 519 | 0.79 | 0.86 | 58 | empty |
| 2 | 52 | 0.26 | 0.74 | 18 | empty |
Interfaces
4 interfaces between chains.
- C–D · 577 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 568 Ų buried · 12 hydrogen bonds · protein-protein
- D–E · 420 Ų buried · 1 hydrogen bond · protein-protein
- A–E · 254 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 35 disulfide (disulfide).
Compared structures
- 2HNV · Crystal Structure of a Dipeptide Complex of the Q58V Mutant of Bovine Neurophysin-I · the same entry in another collection · chain A against A, TM-score 1.00
- P01175 · AlphaFold monomer V2.0 prediction for oxytocin-neurophysin 1 (P01175) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01175
- Elsewhere: RCSB PDB 2HNV · PDBe 2HNV · UniProt P01175
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