MolNFT v1 · #39117 · protein

Crystal structure of mevalonate diphosphate decarboxylase from staphylococcus aureus (monoclinic form)

2HK2 · Diphosphomevalonate decarboxylase: “Crystal structure of mevalonate diphosphate decarboxylase from staphylococcus aureus (monoclinic form)”. X-ray diffraction, 5 pockets (best druggability 0.76). MolNFT v1 #39117 on GenesisL1: 3D…

PDB: 2HK2
Type: protein
Length: 662 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Diphosphomevalonate decarboxylase
EC: 4.1.1.33
UniProt: Q2FJ52
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Diphosphomevalonate decarboxylase (EC 4.1.1.33)	protein	331	42% helix, 26% strand	Q2FJ52

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	541	0.76	0.83	58	empty
2	602	0.76	0.82	67	empty
3	164	0.53	0.80	28	empty
4	81	0.38	0.77	16	empty
5	80	0.33	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 1156 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2HK2 · Crystal structure of mevalonate diphosphate decarboxylase from Staphylococcus aureus… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2FJ52
Elsewhere: RCSB PDB 2HK2 · PDBe 2HK2 · UniProt Q2FJ52

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