MolNFT v1 · #39026 · protein
NMR structure of human insulin mutant gly-B8-D-ser, his-B10-asp pro- B28-lys, lys-B29-pro, 20 structures
2HH4 · Insulin a chain: “NMR structure of human insulin mutant gly-B8-D-ser, his-B10-asp pro- B28-lys, lys-B29-pro, 20 structures”. Solution nmr. MolNFT v1 #39026 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2HH4
- Type
- protein
- Length
- 51 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin a chain; Insulin B chain
- UniProt
- Q5EEX2
Structure
solution nmr · 2 distinct chains · 47% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin a chain | protein | 21 | 57% helix, 5% strand | Q5EEX2 |
| B | Insulin B chain | protein | 30 | 40% helix, 3% strand | Q5EEX2 |
Interfaces
1 interface between chains.
- A–B · 702 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide, 1 d-amino (disulfide, D-amino acid).
Compared structures
- 2HH4 · NMR structure of human insulin mutant GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5EEX2
- Elsewhere: RCSB PDB 2HH4 · PDBe 2HH4 · UniProt Q5EEX2
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