MolNFT v1 · #38950 · protein

Crystal structure of a mutant EPHA4 kinase domain (Y742A)

2HEL · Eph receptor A4: “Crystal structure of a mutant EPHA4 kinase domain (Y742A)”. X-ray diffraction, 1 pocket (best druggability 0.61). MolNFT v1 #38950 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2HEL
Type: protein
Length: 256 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eph receptor A4
UniProt: Q80VZ2
Pockets: 1 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eph receptor A4	protein	256	42% helix, 18% strand	Q80VZ2

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	309	0.61	0.79	40	empty

Compared structures

2HEL · Crystal structure of a mutant EphA4 kinase domain (Y742A) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q80VZ2
Elsewhere: RCSB PDB 2HEL · PDBe 2HEL · UniProt Q80VZ2

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