MolNFT v1 · #38895 · protein

Crystal structure of RNA dependant RNA polymerase domain of west nile virus

2HCS · RNA-directed RNA polymerase (NS5): “Crystal structure of RNA dependant RNA polymerase domain of west nile virus”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.74). MolNFT v1 #38895 on GenesisL1: 3D structure…

PDB: 2HCS
Type: protein
Length: 487 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase (NS5)
EC: 2.7.7.48
UniProt: P14335
Ligands: ZN
Pockets: 6 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase (NS5) (EC 2.7.7.48)	protein	487	54% helix, 6% strand	P14335

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	599	0.74	0.81	45	empty
2	72	0.63	0.91	23	empty
3	87	0.48	0.82	18	empty
4	61	0.45	0.83	16	empty
5	63	0.35	0.77	14	ZN

Compared structures

2HCS · Crystal structure of RNA dependant RNA polymerase domain of West Nile virus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14335
Elsewhere: RCSB PDB 2HCS · PDBe 2HCS · UniProt P14335

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