MolNFT v1 · #3888 · protein

Structure of pokeweed antiviral protein complexed with guanine

1D6A: “Structure of pokeweed antiviral protein complexed with guanine”. X-ray diffraction, 1 ligand (GUN), 2 pockets (best druggability 0.49). MolNFT v1 #3888 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1D6A
Type: protein
Length: 524 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pokeweed antiviral protein
EC: 3.2.2.22
UniProt: P10297
Ligands: GUN
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Pokeweed antiviral protein (EC 3.2.2.22)	protein	262	40% helix, 24% strand	P10297

Ligands and binding sites

GUN · Guanine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	103	0.49	0.81	18	GUN
2	100	0.48	0.81	17	GUN

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1D6A · Structure of pokeweed antiviral protein complexed with guanine · the same entry in another collection · chain A against A, TM-score 1.00
P10297 · AlphaFold monomer V2.0 prediction for antiviral protein I (P10297) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10297
Elsewhere: RCSB PDB 1D6A · PDBe 1D6A · UniProt P10297

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.