MolNFT v1 · #38814 · protein
Methyltransferase domain of human tar (HIV-1) RNA binding protein 1
2HA8 · Tar (HIV-1) RNA loop binding protein: “Methyltransferase domain of human tar (HIV-1) RNA binding protein 1”. X-ray diffraction, 1 ligand (SAH), 2 pockets (best druggability 0.73). MolNFT v1 #38814 on GenesisL1: 3D structure, binding…
- PDB
- 2HA8
- Type
- protein
- Length
- 313 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tar (HIV-1) RNA loop binding protein
- UniProt
- Q13395
- Ligands
- SAH
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tar (HIV-1) RNA loop binding protein | protein | 159 | 41% helix, 18% strand | Q13395 |
| B | Tar (HIV-1) RNA loop binding protein | protein | 154 | 44% helix, 18% strand | Q13395 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 487 | 0.73 | 0.83 | 61 | SAH |
| 2 | 95 | 0.43 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1522 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 2HA8 · Methyltransferase Domain of Human TAR (HIV-1) RNA binding protein 1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q13395 · AlphaFold monomer V2.0 prediction for probable methyltransferase TARBP1 (Q13395) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13395
- Elsewhere: RCSB PDB 2HA8 · PDBe 2HA8 · UniProt Q13395
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