MolNFT v1 · #38749 · protein

Crystal structure of nsp 15 from SARS

2H85 · Putative ORF1AB polyprotein: “Crystal structure of nsp 15 from SARS”. X-ray diffraction, 3 pockets (best druggability 0.64). MolNFT v1 #38749 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2H85
Type: protein
Length: 347 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative ORF1AB polyprotein
UniProt: Q6VA80
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 22% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative ORF1AB polyprotein	protein	347	22% helix, 31% strand	Q6VA80

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	296	0.64	0.81	41	empty
2	87	0.32	0.73	18	empty
3	59	0.28	0.74	18	empty

Compared structures

2H85 · Crystal Structure of Nsp 15 from SARS · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6VA80
Elsewhere: RCSB PDB 2H85 · PDBe 2H85 · UniProt Q6VA80

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