MolNFT v1 · #38743 · protein

Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from trypanosoma cruzi

2H7W: “Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from trypanosoma cruzi”. X-ray diffraction, 1 pocket (best druggability 0.58). MolNFT v1 #38743 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2H7W
Type: protein
Length: 216 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chagasin
UniProt: Q966X9
Pockets: 1 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chagasin	protein	108	6% helix, 51% strand	Q966X9
B	Chagasin	protein	108	6% helix, 49% strand	Q966X9

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	364	0.58	0.75	45	empty

Interfaces

1 interface between chains.

A–B · 308 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2H7W · Crystal structure of Chagasin, the endogenous cysteine-protease inhibitor from… · the same entry in another collection · chain A against A, TM-score 1.00
Q966X9 · AlphaFold monomer V2.0 prediction for chagasin (Q966X9) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q966X9
Elsewhere: RCSB PDB 2H7W · PDBe 2H7W · UniProt Q966X9

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