MolNFT v1 · #38741 · protein

Solution structure of the C-terminal domain of insulin-like growth factor binding protein 2 (igfbp-2)

2H7T · Insulin-like growth factor-binding protein 2: “Solution structure of the C-terminal domain of insulin-like growth factor binding protein 2 (igfbp-2)”. Solution nmr, 4 pockets (best druggability 0.45). MolNFT v1 #38741 on GenesisL1…

PDB: 2H7T
Type: protein
Length: 107 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin-like growth factor-binding protein 2
UniProt: P18065
Pockets: 4 · best druggability 0.45

Structure

solution nmr · 1 distinct chain · 14% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin-like growth factor-binding protein 2	protein	107	14% helix, 11% strand	P18065

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.45	0.81	20	empty
2	108	0.38	0.74	16	empty
3	60	0.34	0.78	11	empty
4	56	0.26	0.73	14	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

2H7T · Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein… · the same entry in another collection · chain A against A, TM-score 1.00
P18065 · AlphaFold monomer V2.0 prediction for insulin-like growth factor- binding protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P18065
Elsewhere: RCSB PDB 2H7T · PDBe 2H7T · UniProt P18065

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