MolNFT v1 · #38740 · protein
L244A mutant of cytochrome P450CAM
2H7S · Cytochrome P450-cam: “L244A mutant of cytochrome P450CAM”. X-ray diffraction, 1 ligand (HEC), 10 pockets (best druggability 0.86). MolNFT v1 #38740 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2H7S
- Type
- protein
- Length
- 810 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome P450-cam
- EC
- 1.14.15.1
- UniProt
- P00183
- Ligands
- HEC
- Pockets
- 10 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Cytochrome P450-cam (EC 1.14.15.1) | protein | 405 | 50% helix, 11% strand | P00183 |
Ligands and binding sites
- HEC · Heme C · ligand · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 443 | 0.86 | 0.93 | 56 | HEC |
| 2 | 437 | 0.86 | 0.93 | 51 | HEC |
| 3 | 307 | 0.60 | 0.78 | 43 | empty |
| 4 | 89 | 0.41 | 0.78 | 17 | empty |
| 5 | 99 | 0.38 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–C · 395 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 cofactor (heme c attachment).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00183
- Elsewhere: RCSB PDB 2H7S · PDBe 2H7S · UniProt P00183
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