MolNFT v1 · #38694 · protein
Crystal structure of the zinc-beta-lactamase L1 from stenotrophomonas maltophilia (mono zinc form)
2H6A · Metallo-beta-lactamase L1: “Crystal structure of the zinc-beta-lactamase L1 from stenotrophomonas maltophilia (mono zinc form)”. X-ray diffraction, 2 ligands (ZN, SO4), 6 pockets (best druggability 0.66). MolNFT v1 #38694 on…
- PDB
- 2H6A
- Type
- protein
- Length
- 532 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metallo-beta-lactamase L1
- EC
- 3.5.2.6
- UniProt
- P52700
- Ligands
- ZN, SO4
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Metallo-beta-lactamase L1 (EC 3.5.2.6) | protein | 266 | 31% helix, 24% strand | P52700 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 235 | 0.66 | 0.84 | 37 | empty |
| 2 | 123 | 0.45 | 0.77 | 28 | SO4 |
| 3 | 104 | 0.40 | 0.76 | 23 | SO4 |
| 4 | 60 | 0.29 | 0.74 | 20 | empty |
| 5 | 60 | 0.27 | 0.73 | 19 | SO4 |
Interfaces
1 interface between chains.
- A–B · 1284 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2H6A · Crystal structure of the zinc-beta-lactamase L1 from Stenotrophomonas maltophilia (mono… · the same entry in another collection · chain A against A, TM-score 1.00
- P52700 · AlphaFold monomer V2.0 prediction for metallo-beta-lactamase L1 type 3 (P52700) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52700
- Elsewhere: RCSB PDB 2H6A · PDBe 2H6A · UniProt P52700
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