MolNFT v1 · #38655 · protein
Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein HSP26
2H50: “Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein HSP26”. Electron microscopy, 20 pockets (best druggability 0.55). MolNFT v1 #38655 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2H50
- Type
- protein
- Length
- 2,232 residues
- Chains
- 24
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small heat shock protein HSP26
- Pockets
- 20 · best druggability 0.55
Structure
electron microscopy · 1 distinct chain · 6% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | Small heat shock protein HSP26 | protein | 93 | 6% helix, 49% strand | — |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 186 | 0.55 | 0.79 | 29 | empty |
| 2 | 198 | 0.54 | 0.79 | 29 | empty |
| 3 | 201 | 0.54 | 0.78 | 29 | empty |
| 4 | 194 | 0.54 | 0.79 | 28 | empty |
| 5 | 208 | 0.53 | 0.78 | 30 | empty |
Interfaces
12 interfaces between chains.
- C–D · 1560 Ų buried · 37 hydrogen bonds · protein-protein
- G–H · 1560 Ų buried · 37 hydrogen bonds · protein-protein
- U–V · 1558 Ų buried · 37 hydrogen bonds · protein-protein
- W–X · 1558 Ų buried · 37 hydrogen bonds · protein-protein
- I–J · 1557 Ų buried · 37 hydrogen bonds · protein-protein
Compared structures
- 2H50 · Multiple distinct assemblies reveal conformational flexibility in the small heat shock… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2H50 · PDBe 2H50
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