MolNFT v1 · #38650 · protein
Crystal structure of the human tyrosine receptor phosphatase gamma
2H4V · Receptor-type tyrosine-protein phosphatase gamma: “Crystal structure of the human tyrosine receptor phosphatase gamma”. X-ray diffraction, 2 ligands (NA, CL), 3 pockets (best druggability 0.79). MolNFT v1 #38650 on GenesisL1: 3D…
- PDB
- 2H4V
- Type
- protein
- Length
- 558 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase gamma
- EC
- 3.1.3.48
- UniProt
- P23470
- Ligands
- NA, CL
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase gamma (EC 3.1.3.48) | protein | 278 | 40% helix, 21% strand | P23470 |
| B | Receptor-type tyrosine-protein phosphatase gamma (EC 3.1.3.48) | protein | 280 | 38% helix, 24% strand | P23470 |
Ligands and binding sites
- NA · Sodium ion · metal · chains B
- CL · Chloride ion · ion · 7 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 5 copies · chains A, B
- ACT · Acetate ion · additive · 2 copies · chains A, B
- FLC · Citrate anion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 918 | 0.79 | 0.82 | 75 | ACT, EDO, CL |
| 2 | 117 | 0.43 | 0.77 | 24 | CL |
| 3 | 62 | 0.33 | 0.77 | 12 | EDO |
Interfaces
1 interface between chains.
- A–B · 493 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2H4V · Crystal Structure of the Human Tyrosine Receptor Phosphatase Gamma · the same entry in another collection · chain A against A, TM-score 1.00
- P23470 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase gamma… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23470
- Elsewhere: RCSB PDB 2H4V · PDBe 2H4V · UniProt P23470
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