MolNFT v1 · #38645 · protein

Crystal structure of wildtype ment in the cleaved conformation

2H4P · Heterochromatin-associated protein ment: “Crystal structure of wildtype ment in the cleaved conformation”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #38645 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 2H4P
Type: protein
Length: 383 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heterochromatin-associated protein ment
UniProt: O73790
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heterochromatin-associated protein ment	protein	350	33% helix, 33% strand	O73790
B	Heterochromatin-associated protein ment	protein	33	0% helix, 58% strand	O73790

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.45	0.82	20	empty

Interfaces

1 interface between chains.

A–B · 2429 Å² buried · 39 hydrogen bonds · protein-protein

Compared structures

2H4P · Crystal structure of wildtype MENT in the cleaved conformation · the same entry in another collection · chain A against A, TM-score 1.00
O73790 · AlphaFold monomer V2.0 prediction for heterochromatin-associated protein ment (O73790) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O73790
Elsewhere: RCSB PDB 2H4P · PDBe 2H4P · UniProt O73790

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