MolNFT v1 · #38641 · protein
Complex of PMM/PGM with ribose 1-phosphate
2H4L · PHOSPHOMANNOMUTASE/PHOSPHOGLUCOMUTASE: “Complex of PMM/PGM with ribose 1-phosphate”. X-ray diffraction, 2 ligands (R1P, ZN), 4 pockets (best druggability 0.68). MolNFT v1 #38641 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2H4L
- Type
- protein
- Length
- 455 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PHOSPHOMANNOMUTASE/PHOSPHOGLUCOMUTASE
- EC
- 5.4.2.8, 5.4.2.2
- UniProt
- P26276
- Ligands
- R1P, ZN
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | PHOSPHOMANNOMUTASE/PHOSPHOGLUCOMUTASE (EC 5.4.2.8, 5.4.2.2) | protein | 455 | 37% helix, 25% strand | P26276 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 374 | 0.68 | 0.81 | 57 | R1P |
| 2 | 117 | 0.49 | 0.80 | 18 | empty |
| 3 | 114 | 0.38 | 0.74 | 22 | empty |
| 4 | 75 | 0.35 | 0.76 | 18 | empty |
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26276
- Elsewhere: RCSB PDB 2H4L · PDBe 2H4L · UniProt P26276
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.