MolNFT v1 · #38566 · protein
Crystal structure of yeeu from E. COLI. northeast structural genomics target ER304
2H28 · Hypothetical protein yeeu: “Crystal structure of yeeu from E. COLI. northeast structural genomics target ER304”. X-ray diffraction, 2 ligands (MG, CL), 2 pockets (best druggability 0.53). MolNFT v1 #38566 on GenesisL1: 3D structure…
- PDB
- 2H28
- Type
- protein
- Length
- 213 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein yeeu
- UniProt
- P76364
- Ligands
- MG, CL
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical protein yeeu | protein | 109 | 25% helix, 33% strand | P76364 |
| B | Hypothetical protein yeeu | protein | 104 | 26% helix, 35% strand | P76364 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
- CL · Chloride ion · ion · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.53 | 0.80 | 30 | GOL |
| 2 | 140 | 0.46 | 0.77 | 21 | MG |
Interfaces
1 interface between chains.
- A–B · 554 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 2H28 · Crystal structure of YeeU from E. coli. Northeast Structural Genomics target ER304 · the same entry in another collection · chain A against A, TM-score 1.00
- P76364 · AlphaFold monomer V2.0 prediction for cytoskeleton bundling-enhancing antitoxin cbea… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P76364
- Elsewhere: RCSB PDB 2H28 · PDBe 2H28 · UniProt P76364
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