MolNFT v1 · #38551 · protein

Crystal structure of a dimethyladenosine transferase from plasmodium falciparum

2H1R · Dimethyladenosine transferase, putative: “Crystal structure of a dimethyladenosine transferase from plasmodium falciparum”. X-ray diffraction, 5 pockets (best druggability 0.75). MolNFT v1 #38551 on GenesisL1: 3D structure, binding…

PDB: 2H1R
Type: protein
Length: 546 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dimethyladenosine transferase, putative
UniProt: Q8ILT8
Pockets: 5 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dimethyladenosine transferase, putative	protein	271	46% helix, 17% strand	Q8ILT8
B	Dimethyladenosine transferase, putative	protein	275	46% helix, 19% strand	Q8ILT8

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	296	0.75	0.87	37	empty
2	264	0.64	0.81	39	empty
3	251	0.61	0.80	37	empty
4	293	0.61	0.79	40	empty
5	50	0.31	0.77	13	empty

Interfaces

1 interface between chains.

A–B · 997 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2H1R · Crystal structure of a dimethyladenosine transferase from Plasmodium falciparum · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8ILT8
Elsewhere: RCSB PDB 2H1R · PDBe 2H1R · UniProt Q8ILT8

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