MolNFT v1 · #38550 · protein

The three-dimensional structures of a polysaccharide binding antibody to cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes

2H1P · 2H1: “The three-dimensional structures of a polysaccharide binding antibody to cryptococcus neoformans and its…”. X-ray diffraction, 3 pockets (best druggability 0.44). MolNFT v1 #38550 on GenesisL1: 3D structure, binding sites and…

PDB: 2H1P
Type: protein
Length: 450 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 2H1; PA1
Pockets: 3 · best druggability 0.44

Structure

x-ray diffraction · 3 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	2H1	protein	219	6% helix, 50% strand	—
H	2H1	protein	220	7% helix, 50% strand	—
P	PA1	protein	11	0% helix, 9% strand	—

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	178	0.44	0.74	29	empty
2	99	0.35	0.74	25	empty
3	78	0.33	0.75	21	empty

Interfaces

3 interfaces between chains.

L–H · 1962 Å² buried · 19 hydrogen bonds · protein-protein
L–P · 364 Å² buried · 5 hydrogen bonds · protein-protein
H–P · 339 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2H1P · The three-dimensional structures of a polysaccharide binding antibody to cryptococcus… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2H1P · PDBe 2H1P

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