MolNFT v1 · #38538 · protein

Resa pH 9.25

2H1D · Thiol-disulfide oxidoreductase resa: “Resa pH 9.25”. X-ray diffraction, 1 pocket (best druggability 0.53). MolNFT v1 #38538 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2H1D
Type: protein
Length: 273 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thiol-disulfide oxidoreductase resa
UniProt: P35160
Pockets: 1 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thiol-disulfide oxidoreductase resa	protein	136	38% helix, 27% strand	P35160
B	Thiol-disulfide oxidoreductase resa	protein	137	36% helix, 28% strand	P35160

Ligands and binding sites

EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	191	0.53	0.79	34	empty

Interfaces

1 interface between chains.

A–B · 389 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2H1D · ResA pH 9.25 · the same entry in another collection · chain A against A, TM-score 1.00
P35160 · AlphaFold monomer V2.0 prediction for thiol-disulfide oxidoreductase resa (P35160) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35160
Elsewhere: RCSB PDB 2H1D · PDBe 2H1D · UniProt P35160

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