MolNFT v1 · #38451 · protein
2.7 a structure of the extracellular domains of the human beta common receptor involved in il-3, il-5, and gm-csf signalling
2GYS · Cytokine receptor common beta chain: “2.7 a structure of the extracellular domains of the human beta common receptor involved in il-3, il-5, and…”. X-ray diffraction, 3 ligands (NAG, FUC, BMA), 8 pockets (best druggability 0.49).…
- PDB
- 2GYS
- Type
- protein
- Length
- 803 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytokine receptor common beta chain
- Ligands
- NAG, FUC, BMA
- Pockets
- 8 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytokine receptor common beta chain | protein | 397 | 6% helix, 47% strand | — |
| B | Cytokine receptor common beta chain | protein | 406 | 6% helix, 47% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- FUC · alpha-L-fucopyranose · sugar · 4 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 2 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.49 | 0.81 | 17 | empty |
| 2 | 256 | 0.48 | 0.73 | 37 | empty |
| 3 | 137 | 0.46 | 0.77 | 25 | empty |
| 4 | 191 | 0.43 | 0.73 | 21 | empty |
| 5 | 136 | 0.39 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 4941 Ų buried · 84 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 2GYS · 2.7 A structure of the extracellular domains of the human beta common receptor involved… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2GYS · PDBe 2GYS
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