MolNFT v1 · #38450 · protein

Crystal structure of human artemin

2GYR · Neurotrophic factor artemin, isoform 3: “Crystal structure of human artemin”. X-ray diffraction, 5 pockets (best druggability 0.77). MolNFT v1 #38450 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2GYR
Type: protein
Length: 582 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurotrophic factor artemin, isoform 3
UniProt: Q5T4W7
Pockets: 5 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Neurotrophic factor artemin, isoform 3	protein	97	16% helix, 41% strand	Q5T4W7

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	807	0.77	0.81	74	empty
2	161	0.41	0.74	28	empty
3	86	0.36	0.76	25	empty
4	76	0.36	0.77	27	empty
5	68	0.27	0.72	14	empty

Interfaces

9 interfaces between chains.

C–D · 1667 Å² buried · 25 hydrogen bonds · protein-protein
E–F · 1661 Å² buried · 29 hydrogen bonds · protein-protein
A–B · 1654 Å² buried · 29 hydrogen bonds · protein-protein
C–E · 197 Å² buried · 1 hydrogen bond · protein-protein
D–E · 133 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 21 disulfide (disulfide).

Compared structures

2GYR · Crystal structure of human artemin · the same entry in another collection · chain F against F, TM-score 1.00
Q5T4W7 · AlphaFold monomer V2.0 prediction for artemin (Q5T4W7) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5T4W7
Elsewhere: RCSB PDB 2GYR · PDBe 2GYR · UniProt Q5T4W7

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