MolNFT v1 · #38322 · protein

Crystal structure of aminopeptidase N from human pathogen neisseria meningitidis

2GTQ: “Crystal structure of aminopeptidase N from human pathogen neisseria meningitidis”. X-ray diffraction, 2 ligands (ZN, SO4), 7 pockets (best druggability 0.84). MolNFT v1 #38322 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2GTQ
Type: protein
Length: 864 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aminopeptidase N
EC: 3.4.11.2
UniProt: Q9JYV4
Ligands: ZN, SO4
Pockets: 7 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aminopeptidase N (EC 3.4.11.2)	protein	864	45% helix, 22% strand	Q9JYV4

Ligands and binding sites

ZN · Zinc ion · metal · chains A
SO4 · Sulfate ion · ion · 16 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1028	0.84	0.85	122	SO4
2	368	0.70	0.83	49	SO4
3	475	0.64	0.77	48	empty
4	200	0.50	0.76	33	empty
5	160	0.46	0.76	27	empty

Modifications

Observed in the structure: 18 modified (engineered).

Compared structures

2GTQ · Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9JYV4
Elsewhere: RCSB PDB 2GTQ · PDBe 2GTQ · UniProt Q9JYV4

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