MolNFT v1 · #38301 · protein

Solution structure of apo human SCO1

2GT5 · SCO1 protein homolog, mitochondrial: “Solution structure of apo human SCO1”. Solution nmr, 4 pockets (best druggability 0.61). MolNFT v1 #38301 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2GT5
Type: protein
Length: 173 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SCO1 protein homolog, mitochondrial
UniProt: O75880
Pockets: 4 · best druggability 0.61

Structure

solution nmr · 1 distinct chain · 27% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SCO1 protein homolog, mitochondrial	protein	173	27% helix, 16% strand	O75880

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.61	0.90	17	empty
2	284	0.60	0.79	38	empty
3	74	0.59	0.88	17	empty
4	102	0.38	0.75	16	empty

Compared structures

2GT5 · Solution structure of apo Human Sco1 · the same entry in another collection · chain A against A, TM-score 1.00
O75880 · AlphaFold monomer V2.0 prediction for protein SCO1 homolog, mitochondrial (O75880) · a predicted model of the same protein · chain A against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75880
Elsewhere: RCSB PDB 2GT5 · PDBe 2GT5 · UniProt O75880

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