MolNFT v1 · #38152 · protein

The crystal structure of the enzyme fe-superoxide dismutase from plasmodium falciparum

2GOJ: “The crystal structure of the enzyme fe-superoxide dismutase from plasmodium falciparum”. X-ray diffraction, 1 ligand (FE2), 3 pockets (best druggability 0.57). MolNFT v1 #38152 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 2GOJ
Type: protein
Length: 391 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fe-superoxide dismutase
EC: 1.15.1.1
Ligands: FE2
Pockets: 3 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 53% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fe-superoxide dismutase (EC 1.15.1.1)	protein	196	53% helix, 12% strand	—
B	Fe-superoxide dismutase (EC 1.15.1.1)	protein	195	54% helix, 12% strand	—

Ligands and binding sites

FE2 · Fe (II) ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	223	0.57	0.79	23	empty
2	225	0.55	0.78	21	empty
3	74	0.31	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 999 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

2GOJ · The crystal structure of the enzyme Fe-superoxide dismutase from Plasmodium falciparum · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2GOJ · PDBe 2GOJ

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