Design of specific peptide inhibitors of phospholipase A2: crystal structure of the complex formed between a group II phospholipase A2 and a designed pentapeptide ala- leu- val- tyr- lys at 2.3 a resolution

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 9% strand (DSSP).

Ligands and binding sites

• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–P · 534 Ų buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

• 2GNS · Design of specific peptide inhibitors of phospholipase A2: Crystal structure of the… · the same entry in another collection · chain A against A, TM-score 1.00
• P59071 · AlphaFold monomer V2.0 prediction for basic phospholipase A2 vrv-pl- viiia (P59071) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P59071
• Elsewhere: RCSB PDB 2GNS · PDBe 2GNS · UniProt P59071