MolNFT v1 · #38035 · protein
Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded dnas without sequence specificity
2GKI · Nuclease: “Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and…”. X-ray diffraction, 2 pockets (best druggability 0.28). MolNFT v1 #38035 on GenesisL1: 3D structure, binding sites…
- PDB
- 2GKI
- Type
- protein
- Length
- 473 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclease
- Pockets
- 2 · best druggability 0.28
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclease | protein | 235 | 8% helix, 52% strand | — |
| B | Nuclease | protein | 238 | 5% helix, 51% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.28 | 0.73 | 12 | empty |
| 2 | 65 | 0.27 | 0.72 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 914 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2GKI · Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2GKI · PDBe 2GKI
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