MolNFT v1 · #38024 · protein
Structure of catalytic elimination antibody 13G5 from a twinned crystal in space group C2
2GK0 · Catalytic elimination antibody 13G5 light chain: “Structure of catalytic elimination antibody 13G5 from a twinned crystal in space group C2”. X-ray diffraction, 14 pockets (best druggability 0.77). MolNFT v1 #38024 on GenesisL1: 3D…
- PDB
- 2GK0
- Type
- protein
- Length
- 871 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Catalytic elimination antibody 13G5 light chain; Catalytic elimination antibody 13G5…
- UniProt
- Q65ZC0, Q91Z05
- Pockets
- 14 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 4% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, A | Catalytic elimination antibody 13G5 light chain | protein | 217 | 4% helix, 47% strand | Q65ZC0 |
| H | Catalytic elimination antibody 13G5 heavy chain | protein | 221 | 4% helix, 44% strand | Q91Z05 |
| B | Catalytic elimination antibody 13G5 heavy chain | protein | 216 | 4% helix, 38% strand | Q91Z05 |
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 900 | 0.77 | 0.80 | 91 | empty |
| 2 | 577 | 0.61 | 0.74 | 51 | empty |
| 3 | 343 | 0.60 | 0.77 | 41 | empty |
| 4 | 75 | 0.59 | 0.89 | 23 | empty |
| 5 | 139 | 0.58 | 0.84 | 26 | empty |
Interfaces
4 interfaces between chains.
- L–H · 1793 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 1622 Ų buried · 14 hydrogen bonds · protein-protein
- L–A · 331 Ų buried · 6 hydrogen bonds · protein-protein
- L–B · 275 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2GK0 · Structure of Catalytic Elimination Antibody 13G5 from a twinned crystal in space group C2 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q65ZC0
- Every structure of UniProt Q91Z05
- Elsewhere: RCSB PDB 2GK0 · PDBe 2GK0 · UniProt Q65ZC0 · UniProt Q91Z05
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