MolNFT v1 · #37987 · protein
Human myst histone acetyltransferase 1
2GIV · Probable histone acetyltransferase MYST1: “Human myst histone acetyltransferase 1”. X-ray diffraction, 3 ligands (ACO, ZN, CL), 2 pockets (best druggability 0.71). MolNFT v1 #37987 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2GIV
- Type
- protein
- Length
- 258 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable histone acetyltransferase MYST1
- EC
- 2.3.1.48
- Ligands
- ACO, ZN, CL
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable histone acetyltransferase MYST1 (EC 2.3.1.48) | protein | 258 | 32% helix, 25% strand | — |
Ligands and binding sites
- ACO · Acetyl coenzyme *A · ligand · chains A
- ZN · Zinc ion · metal · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 311 | 0.71 | 0.84 | 37 | ACO |
| 2 | 54 | 0.42 | 0.82 | 18 | empty |
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 2GIV · Human MYST histone acetyltransferase 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2GIV · PDBe 2GIV
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