MolNFT v1 · #37970 · protein
Crystal structures of trypanosoma bruciei MRP1/MRP2
2GID · Mitochondrial RNA-binding protein 2: “Crystal structures of trypanosoma bruciei MRP1/MRP2”. X-ray diffraction, 15 pockets (best druggability 0.75). MolNFT v1 #37970 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2GID
- Type
- protein
- Length
- 1,187 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial RNA-binding protein 2; Mitochondrial RNA-binding protein 1
- UniProt
- Q952G2, P90629
- Pockets
- 15 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 21% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial RNA-binding protein 2 | protein | 150 | 21% helix, 35% strand | Q952G2 |
| B, D, K, J | Mitochondrial RNA-binding protein 1 | protein | 146 | 23% helix, 36% strand | P90629 |
| G, H, P | Mitochondrial RNA-binding protein 2 | protein | 151 | 19% helix, 39% strand | Q952G2 |
Pockets
15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 800 | 0.75 | 0.80 | 60 | empty |
| 2 | 702 | 0.73 | 0.79 | 46 | empty |
| 3 | 533 | 0.69 | 0.79 | 65 | empty |
| 4 | 228 | 0.56 | 0.79 | 33 | empty |
| 5 | 234 | 0.55 | 0.78 | 32 | empty |
Interfaces
11 interfaces between chains.
- K–P · 1209 Ų buried · 8 hydrogen bonds · protein-protein
- B–G · 1152 Ų buried · 12 hydrogen bonds · protein-protein
- H–J · 1149 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 1058 Ų buried · 7 hydrogen bonds · protein-protein
- D–G · 748 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified (engineered).
Compared structures
- 2GID · Crystal structures of trypanosoma bruciei MRP1/MRP2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q952G2
- Every structure of UniProt P90629
- Elsewhere: RCSB PDB 2GID · PDBe 2GID · UniProt Q952G2 · UniProt P90629
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