MolNFT v1 · #37968 · protein

Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain

2GIB: “Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.43). MolNFT v1 #37968 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2GIB
Type: protein
Length: 193 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleocapsid protein
UniProt: P59595
Ligands: SO4
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleocapsid protein	protein	97	42% helix, 20% strand	P59595
B	Nucleocapsid protein	protein	96	38% helix, 21% strand	P59595

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	110	0.43	0.77	17	empty
2	51	0.25	0.73	22	empty

Interfaces

1 interface between chains.

A–B · 2153 Å² buried · 33 hydrogen bonds · protein-protein

Compared structures

2GIB · Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P59595
Elsewhere: RCSB PDB 2GIB · PDBe 2GIB · UniProt P59595

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