MolNFT v1 · #37938 · protein

Thermotoga maritima maltotriose binding protein bound with maltotriose

2GHA · Maltose ABC transporter, periplasmic maltose-binding protein: “Thermotoga maritima maltotriose binding protein bound with maltotriose”. X-ray diffraction, 1 ligand (GLC), 6 pockets (best druggability 0.77). MolNFT v1 #37938 on…

PDB: 2GHA
Type: protein
Length: 747 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Maltose ABC transporter, periplasmic maltose-binding protein
Ligands: GLC
Pockets: 6 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Maltose ABC transporter, periplasmic maltose-binding protein	protein	374	47% helix, 22% strand	—
B	Maltose ABC transporter, periplasmic maltose-binding protein	protein	373	48% helix, 21% strand	—

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1166	0.77	0.79	108	empty
2	285	0.70	0.84	29	GLC
3	377	0.68	0.81	28	GLC
4	173	0.47	0.75	32	empty
5	125	0.38	0.73	24	empty

Interfaces

1 interface between chains.

A–B · 662 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2GHA · Thermotoga maritima maltotriose binding protein bound with maltotriose · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2GHA · PDBe 2GHA

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