MolNFT v1 · #37885 · protein

Structure of the multidrug transporter emrd from escherichia COLI

2GFP · Multidrug resistance protein D: “Structure of the multidrug transporter emrd from escherichia COLI”. X-ray diffraction, 14 pockets (best druggability 0.88). MolNFT v1 #37885 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2GFP
Type: protein
Length: 750 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multidrug resistance protein D
UniProt: P31442
Pockets: 14 · best druggability 0.88

Structure

x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Multidrug resistance protein D	protein	375	79% helix, 0% strand	P31442

Pockets

14 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	437	0.88	0.95	59	empty
2	253	0.83	0.95	36	empty
3	178	0.79	0.94	32	empty
4	134	0.77	0.94	29	empty
5	135	0.76	0.94	31	empty

Interfaces

1 interface between chains.

A–B · 305 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2GFP · Structure of the Multidrug Transporter EmrD from Escherichia coli · the same entry in another collection · chain A against A, TM-score 1.00
P31442 · AlphaFold monomer V2.0 prediction for multidrug resistance protein D (P31442) · a predicted model of the same protein · chain A against A, TM-score 0.73

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31442
Elsewhere: RCSB PDB 2GFP · PDBe 2GFP · UniProt P31442

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