MolNFT v1 · #37793 · protein

Crystal structure of the human rhoc-gsp complex

2GCP · Rho-related GTP-binding protein rhoc: “Crystal structure of the human rhoc-gsp complex”. X-ray diffraction, 2 ligands (GSP, MG), 1 pocket (best druggability 0.56). MolNFT v1 #37793 on GenesisL1: 3D structure, binding sites and…

PDB: 2GCP
Type: protein
Length: 178 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rho-related GTP-binding protein rhoc
UniProt: P08134
Ligands: GSP, MG
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rho-related GTP-binding protein rhoc	protein	178	39% helix, 25% strand	P08134

Ligands and binding sites

GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · chains A
MG · Magnesium ion · metal · 3 copies · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	151	0.56	0.82	34	MG, GSP, EDO

Compared structures

2GCP · Crystal structure of the human RhoC-GSP complex · the same entry in another collection · chain A against A, TM-score 1.00
P08134 · AlphaFold monomer V2.0 prediction for rho-related GTP-binding protein rhoc (P08134) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08134
Elsewhere: RCSB PDB 2GCP · PDBe 2GCP · UniProt P08134

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