MolNFT v1 · #37776 · protein
S73A mutant of L. casei fpgs
2GC6 · Folylpolyglutamate synthase: “S73A mutant of L. casei fpgs”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.68). MolNFT v1 #37776 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2GC6
- Type
- protein
- Length
- 407 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Folylpolyglutamate synthase
- EC
- 6.3.2.17
- UniProt
- P15925
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Folylpolyglutamate synthase (EC 6.3.2.17) | protein | 407 | 42% helix, 18% strand | P15925 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 549 | 0.68 | 0.78 | 58 | SO4 |
| 2 | 100 | 0.46 | 0.80 | 20 | empty |
| 3 | 98 | 0.41 | 0.77 | 20 | empty |
| 4 | 98 | 0.35 | 0.74 | 21 | empty |
Modifications
Observed in the structure: 1 modified (carboxylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15925
- Elsewhere: RCSB PDB 2GC6 · PDBe 2GC6 · UniProt P15925
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.