MolNFT v1 · #37713 · protein
Crystal structure of YFH7 from saccharomyces cerevisiae: a putative P-loop containing kinase with a circular permutation.
2GA8 · Hypothetical 39.9 kda protein: “Crystal structure of YFH7 from saccharomyces cerevisiae: a putative P-loop containing kinase with a circular…”. X-ray diffraction, 2 ligands (HG, SO4), 2 pockets (best druggability 0.66). MolNFT v1…
- PDB
- 2GA8
- Type
- protein
- Length
- 329 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical 39.9 kda protein
- UniProt
- P43591
- Ligands
- HG, SO4
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical 39.9 kda protein | protein | 329 | 39% helix, 20% strand | P43591 |
Ligands and binding sites
- HG · Mercury (II) ion · metal · 4 copies · chains A
- SO4 · Sulfate ion · ion · 5 copies · chains A
- BME · Beta-mercaptoethanol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 478 | 0.66 | 0.78 | 42 | SO4, HG, BME |
| 2 | 67 | 0.33 | 0.76 | 16 | empty |
Modifications
Observed in the structure: 3 modified (artifact).
Compared structures
- 2GA8 · Crystal structure of YFH7 from Saccharomyces cerevisiae: a putative P-loop containing… · the same entry in another collection · chain A against A, TM-score 1.00
- P43591 · AlphaFold monomer V2.0 prediction for ATP-dependent kinase YFH7 (P43591) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43591
- Elsewhere: RCSB PDB 2GA8 · PDBe 2GA8 · UniProt P43591
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