MolNFT v1 · #37673 · RNA

Crystal structure analysis of the RNA dodecamer cgc-(NF2)-aauuagcg, with an incorporated 2,4-difluorotoluyl residue (NF2)

2G92 · 5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3': “Crystal structure analysis of the RNA dodecamer cgc-(NF2)-aauuagcg, with an incorporated 2,4-difluorotoluyl…”. X-ray diffraction, 1 pocket (best druggability 0.51). MolNFT v1 #37673…

PDB: 2G92
Type: RNA
Length: 24 nucleotides
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3'
Pockets: 1 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	5'-R(CPGPCP(NF2)PAPAPUPUPAPGPCPG)-3'	rna	12	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	308	0.51	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 588 Å² buried · 42 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 2 modified (nucleotide modification).

Compared structures

2G92 · Crystal Structure Analysis of the RNA Dodecamer CGC-(NF2)-AAUUAGCG, with an Incorporated… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2G92 · PDBe 2G92

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