MolNFT v1 · #37581 · protein

Structure of anti-flag M2 Fab domain

2G60 · Anti-flag M2 Fab light chain: “Structure of anti-flag M2 Fab domain”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #37581 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2G60
Type: protein
Length: 421 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anti-flag M2 Fab light chain; Anti-flag M2 Fab heavy chain
UniProt: Q65ZC0, Q5BJZ2
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Anti-flag M2 Fab light chain	protein	213	7% helix, 50% strand	Q65ZC0
H	Anti-flag M2 Fab heavy chain	protein	208	7% helix, 53% strand	Q5BJZ2

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	622	0.62	0.74	65	empty
2	138	0.59	0.84	25	empty
3	79	0.55	0.87	21	empty
4	108	0.37	0.74	26	empty

Interfaces

1 interface between chains.

L–H · 1610 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2G60 · Structure of anti-FLAG M2 Fab domain · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q65ZC0
Every structure of UniProt Q5BJZ2
Elsewhere: RCSB PDB 2G60 · PDBe 2G60 · UniProt Q65ZC0 · UniProt Q5BJZ2

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