MolNFT v1 · #37560 · protein
Crystal structure of the catalytic domain of protein tyrosine phosphatase from homo sapiens
2G59 · Receptor-type tyrosine-protein phosphatase O: “Crystal structure of the catalytic domain of protein tyrosine phosphatase from homo sapiens”. X-ray diffraction, 1 ligand (PO4), 7 pockets (best druggability 0.86). MolNFT v1 #37560 on…
- PDB
- 2G59
- Type
- protein
- Length
- 569 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase O
- EC
- 3.1.3.48
- UniProt
- Q16827
- Ligands
- PO4
- Pockets
- 7 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase O (EC 3.1.3.48) | protein | 287 | 38% helix, 20% strand | Q16827 |
| B | Receptor-type tyrosine-protein phosphatase O (EC 3.1.3.48) | protein | 282 | 40% helix, 20% strand | Q16827 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 700 | 0.86 | 0.89 | 50 | empty |
| 2 | 267 | 0.65 | 0.82 | 40 | empty |
| 3 | 154 | 0.46 | 0.76 | 23 | empty |
| 4 | 105 | 0.38 | 0.75 | 24 | empty |
| 5 | 54 | 0.33 | 0.77 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 677 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2G59 · Crystal Structure of the Catalytic Domain of Protein Tyrosine Phosphatase from Homo… · the same entry in another collection · chain A against A, TM-score 1.00
- Q16827 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase O… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16827
- Elsewhere: RCSB PDB 2G59 · PDBe 2G59 · UniProt Q16827
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