MolNFT v1 · #37344 · protein
Structure of a putative phosphoserine aminotransferase from mycobacterium tuberculosis
2FYF: “Structure of a putative phosphoserine aminotransferase from mycobacterium tuberculosis”. X-ray diffraction, 3 ligands (PLP, PC4, SO4), 3 pockets (best druggability 0.77). MolNFT v1 #37344 on GenesisL1: 3D structure, binding sites…
- PDB
- 2FYF
- Type
- protein
- Length
- 736 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoserine aminotransferase
- EC
- 2.6.1.52
- UniProt
- P63514
- Ligands
- PLP, PC4, SO4
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phosphoserine aminotransferase (EC 2.6.1.52) | protein | 368 | 39% helix, 15% strand | P63514 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B
- PC4 · Tetrachloroplatinate(ii) · metal · 6 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- GOL · Glycerol · additive · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 261 | 0.77 | 0.90 | 49 | PLP, SO4 |
| 2 | 241 | 0.76 | 0.90 | 39 | SO4, PLP |
| 3 | 85 | 0.34 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2190 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 2FYF · Structure of a putative phosphoserine aminotransferase from Mycobacterium Tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63514
- Elsewhere: RCSB PDB 2FYF · PDBe 2FYF · UniProt P63514
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