MolNFT v1 · #37330 · protein + RNA
A dual mode of RNA recognition by the rbmy protein
2FY1 · S1A stem-loop RNA: “A dual mode of RNA recognition by the rbmy protein”. Solution nmr, 2 pockets (best druggability 0.38). MolNFT v1 #37330 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2FY1
- Type
- protein + RNA
- Length
- 129 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S1A stem-loop RNA; RNA-binding motif protein, Y chromosome, family 1 member A1
- UniProt
- Q15414
- Pockets
- 2 · best druggability 0.38
Structure
solution nmr · 2 distinct chains · 18% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | S1A stem-loop RNA | rna | 21 | — | — |
| A | RNA-binding motif protein, Y chromosome, family 1 member A1 | protein | 108 | 18% helix, 19% strand | Q15414 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.38 | 0.77 | 18 | empty |
| 2 | 63 | 0.32 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- B–A · 1054 Ų buried · 23 hydrogen bonds · protein-nucleic
Compared structures
- 2FY1 · A dual mode of RNA recognition by the RBMY protein · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15414
- Elsewhere: RCSB PDB 2FY1 · PDBe 2FY1 · UniProt Q15414
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