MolNFT v1 · #37240 · protein

UGL_D88N/DGLCA-glc-rha-glc

2FV0 · Unsaturated glucuronyl hydrolase: “UGL_D88N/DGLCA-glc-rha-glc”. X-ray diffraction, 3 ligands (GAD, BGC, RAM), 5 pockets (best druggability 0.57). MolNFT v1 #37240 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2FV0
Type: protein
Length: 754 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Unsaturated glucuronyl hydrolase
EC: 3.2.1.-
UniProt: Q9RC92
Ligands: GAD, BGC, RAM
Pockets: 5 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Unsaturated glucuronyl hydrolase (EC 3.2.1.-)	protein	377	53% helix, 10% strand	Q9RC92

Ligands and binding sites

GAD · 2,6-anhydro-3-deoxy-L-threo-hex-2-enonic acid · ligand · chains A
BGC · beta-D-glucopyranose · sugar · 2 copies · chains A
RAM · alpha-L-rhamnopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	187	0.57	0.80	23	BGC, GAD
2	126	0.52	0.81	20	empty
3	146	0.37	0.72	23	empty
4	83	0.30	0.72	14	empty
5	54	0.25	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 949 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

2FV0 · UGL_D88N/dGlcA-Glc-Rha-Glc · the same entry in another collection · chain A against A, TM-score 1.00
Q9RC92 · AlphaFold monomer V2.0 prediction for unsaturated glucuronyl hydrolase (Q9RC92) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9RC92
Elsewhere: RCSB PDB 2FV0 · PDBe 2FV0 · UniProt Q9RC92

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