MolNFT v1 · #37238 · protein

Phosphoglucomutase from salmonella typhimurium.

2FUV: “Phosphoglucomutase from salmonella typhimurium.”. X-ray diffraction, 1 ligand (MG), 7 pockets (best druggability 0.64). MolNFT v1 #37238 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2FUV
Type: protein
Length: 1,090 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoglucomutase
EC: 5.4.2.2
UniProt: Q8ZQW9
Ligands: MG
Pockets: 7 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Phosphoglucomutase (EC 5.4.2.2)	protein	545	39% helix, 20% strand	Q8ZQW9

Ligands and binding sites

MG · Magnesium ion · metal · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	382	0.64	0.79	63	empty
2	475	0.60	0.75	53	empty
3	419	0.60	0.76	54	empty
4	76	0.37	0.76	18	empty
5	70	0.37	0.77	18	empty

Interfaces

1 interface between chains.

A–B · 1141 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 20 modified (engineered).

Compared structures

2FUV · Phosphoglucomutase from Salmonella typhimurium. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8ZQW9
Elsewhere: RCSB PDB 2FUV · PDBe 2FUV · UniProt Q8ZQW9

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