MolNFT v1 · #37200 · protein

Crystal structure of hydroxymethylglutaryl-CoA lyase from pseudomonas aeruginosa

2FTP: “Crystal structure of hydroxymethylglutaryl-CoA lyase from pseudomonas aeruginosa”. X-ray diffraction, 1 ligand (NA), 1 pocket (best druggability 0.70). MolNFT v1 #37200 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2FTP
Type: protein
Length: 300 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hydroxymethylglutaryl-CoA lyase
EC: 4.1.3.4
Ligands: NA
Pockets: 1 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	protein	300	47% helix, 18% strand	—

Ligands and binding sites

NA · Sodium ion · metal · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	362	0.70	0.82	37	NA, GOL

Compared structures

2FTP · Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2FTP · PDBe 2FTP

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