MolNFT v1 · #37194 · protein
Bacteriophage HK97 expansion intermediate IV
2FTE · Major capsid protein: “Bacteriophage HK97 expansion intermediate IV”. Electron microscopy, 20 pockets (best druggability 0.78). MolNFT v1 #37194 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2FTE
- Type
- protein
- Length
- 1,906 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major capsid protein
- UniProt
- P49861
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 3 distinct chains · 25% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Major capsid protein | protein | 280 | 24% helix, 33% strand | P49861 |
| F | Major capsid protein | protein | 264 | 25% helix, 33% strand | P49861 |
| G | Major capsid protein | protein | 242 | 27% helix, 26% strand | P49861 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 889 | 0.78 | 0.81 | 109 | empty |
| 2 | 1028 | 0.77 | 0.79 | 114 | empty |
| 3 | 1089 | 0.77 | 0.79 | 134 | empty |
| 4 | 975 | 0.76 | 0.79 | 110 | empty |
| 5 | 758 | 0.76 | 0.81 | 96 | empty |
Interfaces
7 interfaces between chains.
- A–B · 873 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 871 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 865 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 863 Ų buried · 7 hydrogen bonds · protein-protein
- D–E · 849 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2FTE · Bacteriophage HK97 Expansion Intermediate IV · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49861
- Elsewhere: RCSB PDB 2FTE · PDBe 2FTE · UniProt P49861
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