MolNFT v1 · #37091 · protein
Human tryptase with 2-amino benzimidazole
2FPZ · Tryptase beta-2: “Human tryptase with 2-amino benzimidazole”. X-ray diffraction, 1 ligand (270), 9 pockets (best druggability 0.48). MolNFT v1 #37091 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2FPZ
- Type
- protein
- Length
- 972 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptase beta-2
- EC
- 3.4.21.59
- UniProt
- P20231
- Ligands
- 270
- Pockets
- 9 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 10% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Tryptase beta-2 (EC 3.4.21.59) | protein | 243 | 10% helix, 37% strand | P20231 |
Ligands and binding sites
- 270 · 2H-benzoimidazol-2-ylamine · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.48 | 0.76 | 30 | empty |
| 2 | 197 | 0.46 | 0.74 | 29 | empty |
| 3 | 127 | 0.42 | 0.76 | 34 | 270 |
| 4 | 154 | 0.42 | 0.74 | 33 | 270 |
| 5 | 119 | 0.41 | 0.76 | 27 | 270 |
Interfaces
4 interfaces between chains.
- B–C · 1139 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 1125 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 436 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 432 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20231
- Elsewhere: RCSB PDB 2FPZ · PDBe 2FPZ · UniProt P20231
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