MolNFT v1 · #37044 · protein

Structure of restriction endonuclease foki

2FOK · Foki restriction endonuclease: “Structure of restriction endonuclease foki”. X-ray diffraction, 14 pockets (best druggability 0.55). MolNFT v1 #37044 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2FOK
Type: protein
Length: 1,118 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Foki restriction endonuclease
EC: 3.1.21.4
UniProt: P14870
Pockets: 14 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Foki restriction endonuclease (EC 3.1.21.4)	protein	558	48% helix, 13% strand	P14870
B	Foki restriction endonuclease (EC 3.1.21.4)	protein	560	47% helix, 13% strand	P14870

Pockets

14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	348	0.55	0.75	44	empty
2	291	0.54	0.75	41	empty
3	235	0.50	0.75	23	empty
4	61	0.49	0.85	15	empty
5	82	0.48	0.83	23	empty

Interfaces

1 interface between chains.

A–B · 689 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

2FOK · Structure of restriction endonuclease foki · the same entry in another collection · chain A against A, TM-score 1.00
P14870 · AlphaFold monomer V2.0 prediction for type-2 restriction enzyme foki (P14870) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14870
Elsewhere: RCSB PDB 2FOK · PDBe 2FOK · UniProt P14870

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.