MolNFT v1 · #36823 · protein
Avidin related protein (AVR4)-bna complex
2FHL · Avidin-related protein 4/5: “Avidin related protein (AVR4)-bna complex”. X-ray diffraction, 1 ligand (BNI), 2 pockets (best druggability 0.53). MolNFT v1 #36823 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2FHL
- Type
- protein
- Length
- 240 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Avidin-related protein 4/5
- UniProt
- P56734
- Ligands
- BNI
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Avidin-related protein 4/5 | protein | 120 | 8% helix, 50% strand | P56734 |
Ligands and binding sites
- BNI · 5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid (4-nitro-phenyl)-amide · ligand · 2 copies · chains A, B
- FMT · Formic acid · additive · 10 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.53 | 0.80 | 24 | BNI, FMT |
| 2 | 145 | 0.53 | 0.80 | 21 | BNI |
Interfaces
1 interface between chains.
- A–B · 1688 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P56734
- Elsewhere: RCSB PDB 2FHL · PDBe 2FHL · UniProt P56734
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